Neural Signal Processing of Microelectrode Recordings for Deep Brain Stimulation

....................................................................................................................... I Acknowledgement....................................................................................................... II Abbreviations ............................................................................................................. III Preface....................................................................................................................... IV Chapter 1 Background Information ............................................................................. 1 1.1 Parkinson Disease ................................................................................................ 1 1.1.1 Pathology of Parkinson Disease ........................................................................ 1 1.1.2 Treatment for Parkinson Disease ....................................................................... 4 1.2 Deep Brain Stimulation ......................................................................................... 5 1.2.1 Mechanism of Deep Brain Stimulation ............................................................... 5 1.2.2 DBS Procedure .................................................................................................. 6 1.3 Microelectrode Electrode Recording ..................................................................... 7 1.4 Thesis Objective .................................................................................................... 9 1.5 Data Collection ...................................................................................................... 9 1.6 Thesis Work Flow .................................................................................................. 9 Chapter 2 Signal Components Separation ................................................................ 11 2.1 MER Signal Composition .................................................................................... 11 2.2 MER Signal Components Separation Procedure ................................................ 13 2.2.1 Noise Level Estimation ..................................................................................... 13 2.2.2 Spikes & Artifacts Detection ............................................................................. 17 Chapter 3 Feature Extraction .................................................................................... 19 3.1 Signal Characteristics of STN & SN .................................................................... 19 3.2 Signal Types for Feature Extraction .................................................................... 19 3.3 Feature Extraction Method .................................................................................. 20 3.4 Features Based on Artifact Removed Signal ...................................................... 21 3.5 Features Based on Spikes .................................................................................. 26 3.6 Features Based on Interspike Intervals ............................................................... 27 Chapter 4 Resulting Target Localization Algorithm ................................................... 39 4.1 Target Nucleus STN Localization Algorithm ....................................................... 40 4.2 Nucleus SN Locating Algorithm .......................................................................... 45 4.3 Resulting Algorithm Analysis ............................................................................... 46 Chapter 5 Conclusion & Future Work ....................................................................... 49 References ................................................................................................................ 50